Abstract: Endovascular infection with Curvularia is a rare occurrence. Only 2 cases have been previously reported in the literature. One of the cases was fatal, and the other was cured with surgery and antifungal therapy. We describe here an elderly diabetic woman with Curvularia endocarditis of a prosthetic aortic valve. There was extensive systemic embolization including liver, spleen, and brain. Unfortunately, she succumbed to the infection despite valve replacement.