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Response of Human Immunodeficiency Virus–Associated Oral Plasmablastic Lymphoma to Highly Active Antiretroviral Therapy Without Chemotherapy: Case Report and Literature Review

Corti, Marcelo MD*; De Carolis, Luis MD*; Campitelli, Ana MD; Narbaitz, Marina MD; Baré, Patricia MD§

Infectious Diseases in Clinical Practice: January 2012 - Volume 20 - Issue 1 - p 79–81
doi: 10.1097/IPC.0b013e31821618a4
Case Reports

Abstract: Plasmablastic lymphoma (PBL) is a B-cell–derived lymphoma that is described as a subtype of the diffuse large B-cell lymphoma, commonly seen in patients with human immunodeficiency virus infection. The oral cavity is the first site of presentation with local invasion to the palate and the jaw and rapid dissemination to extraoral sites. The characteristic immunophenotype include the presence of plasma cell markers VS38c and CD138. Epstein-Barr virus and human herpes virus type-8 are strongly associated with the pathogenesis of oral PBL.

Here, we describe a case of PBL of the oral cavity in a 55-year-old woman who was only treated with HAART and improved with a full remission of the neoplasm, which is probably related with a good control of the immunological and virological status associated with the highly active antiretroviral therapy.

From the *HIV/AIDS Division, †Histopathology Laboratory, Infectious Diseases Department, F. J. Muñiz Hospital, Buenos Aires, Argentina; ‡Pathology Laboratory, and §Virology Laboratory, National Academy of Medicine, Buenos Aires, Argentina.

Correspondence to: Marcelo Corti, MD, HIV/AIDS Division, Infectious Diseases Department, F. J. Muñiz Hospital, Puán 381 2° C 1406 CQG, 2nd floor, apartment C, Buenos Aires, Argentina, 1406 CQG. E-mail:

Marcelo Corti contributed to the clinical management of the patient, supervised the treatment and the manuscript writing; Luis De Carolis contributed to the clinical management of the patient, collaboration in the manuscript preparation, and prepared the figures; Ana Campitelli, pathologist, contributed to the diagnosis of PBL; Marina Narbaitz, pathologist, contributed to the diagnosis of PBL and immunohistochemical procedures; Patricia Baré, virologist, contributed to the detection of EBV and HHV-8 in the biopsy smears.

The authors have no funding or conflicts of interest to disclose.

© 2012 Lippincott Williams & Wilkins, Inc.