Abstract: Pasteurella multocida is a common cause of soft tissue infections in humans and usually results from a bite by a domestic or wild animal. Pasteurella supraglottitis is rare and likely results from a non-bite animal exposure. We report a case of P. multocida supraglottitis resulting in bacteremia and seeding of a vascular homograft resulting in pseudoaneurysm formation. After surgical repair of the graft and 6 weeks of postoperative antibiotic therapy, the patient resumed normal activities and has continued to do well after 1 year of follow-up. This case illustrates the potential for P. multocida to cause non-bite–associated infections. This is the first report of this zoonotic infection involving a vascular homograft.