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Liedtke, Michelle D. PharmD; Vandaveer, Julie K. PharmD; Greenfield, Ronald A. MD; Lockhart, Staci M. PharmD
Itraconazole is a commonly prescribed antifungal agent that has been associated with the occurrence of congestive heart failure (CHF) symptoms. There is currently a black box warning related to itraconazole stating that its use is contraindicated for the treatment of onychomycosis in patients with left ventricular dysfunction or a history of CHF. We report a case of a man presenting with 3 exacerbations of CHF secondary to itraconazole therapy for disseminated histoplasmosis. He was successfully treated with posaconazole with no recurrence of symptoms.
© 2011 Lippincott Williams & Wilkins, Inc.
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itraconazole, congestive heart failure, histoplasmosis, adverse effect
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