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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3182156810
Case Reports

Congestive Heart Failure Exacerbation Secondary to Itraconazole Therapy

Liedtke, Michelle D. PharmD; Vandaveer, Julie K. PharmD; Greenfield, Ronald A. MD; Lockhart, Staci M. PharmD

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Itraconazole is a commonly prescribed antifungal agent that has been associated with the occurrence of congestive heart failure (CHF) symptoms. There is currently a black box warning related to itraconazole stating that its use is contraindicated for the treatment of onychomycosis in patients with left ventricular dysfunction or a history of CHF. We report a case of a man presenting with 3 exacerbations of CHF secondary to itraconazole therapy for disseminated histoplasmosis. He was successfully treated with posaconazole with no recurrence of symptoms.

© 2011 Lippincott Williams & Wilkins, Inc.

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