Skip Navigation LinksHome > September 2011 - Volume 19 - Issue 5 > Clinical Presentation of 2009 H1N1 Influenza A Disease in HI...
Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3182142fa6
Original Articles

Clinical Presentation of 2009 H1N1 Influenza A Disease in HIV-Infected Patients: Experience From a Large AIDS Center in New York City

Gonzalez, Efrain MD*†; Psevdos, George Jr MD*†; Tsveniashvili, Lia MD*†; Sharp, Victoria MD†

Collapse Box


Background: H1N1-novel Influenza A seemed to take the United States by surprise in the summer of 2009, and it soon reached epidemic proportions, affecting large and varied sections of the population. Immune-compromised patient populations, including human immunodeficiency virus (HIV)-infected individuals, were thought to be at higher risk. The study examined the severity and characteristics of H1N1 Influenza disease in HIV-infected patients and assessed treatment outcomes.

Methods: Retrospective chart review of 2951 HIV-infected patients from May 1, 2009 to December 31, 2009.

Results: Ninety-four patients presented with flulike symptoms, and 25 patients tested positive by culture for H1N1. Only 4 of 25 rapid test results were positive. The mean age was 46 years. Ninety-two percent were on antiretroviral therapy, and 56% were men. The mean CD4+ T-cell count was 496/μL, and viral load was undetectable in 60% of the patients. Ten patients required hospitalization, and 3 received mechanical ventilation. One patient died. Twenty-four patients received osetalmivir, and one patient recovered without treatment. There was no difference between the hospitalized and nonhospitalized patients in the CD4+ T-cell count (P = 0.8462) and viral load (P = 0.5849). Hospitalized patients were older (mean age, 54.3 vs. 41.5 years, P = 0.001), and logistic regression analysis showed that age older than 46 years (OR = 18.000; 95% confidence interval, 1.75-184.68, P = 0.032) was associated with hospitalization.

Conclusions: H1N1 influenza was a rare occurrence in our population. Most of the patients recovered. Older patients were more likely to get hospitalized.

© 2011 Lippincott Williams & Wilkins, Inc.

Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.