Kluyvera is a small, motile, gram-negative bacillus within the Enterobacteriaceae family. It is part of the normal human flora of the respiratory tract and gastrointestinal tract. Although it was originally described as a benign colonizer and saprophyte, Kluyvera has also been described as causing a wide array of serious and potentially life-threatening infections and should not be discounted when isolated from clinical specimens. We report the case of a patient who developed Kluyvera ascorbata bacteremia and probable meningitis. It is the 17th reported case of Kluyvera bacteremia in the literature and would represent the first case of Kluyvera meningitis in a patient without a central nervous system shunt. We review the literature about reported cases of Kluyvera bacteremia and meningitis.