Lancefield group C Streptococcus is an uncommonly reported etiologic agent for pleuropulmonary infection. This report details the case histories of 2 patients with pleuropulmonary infection due to group C Streptococcus. Case 1 is that of a healthy 25-year-old man who presented to the hospital with severe pleuritic chest pain and a cough productive of yellow sputum. Group C Streptococcus was isolated in pure culture from a sputum culture whose Gram-stained smear confirmed gram-positive cocci in chains as the predominant organism. He had cavitary pulmonary infiltrates on computerized scanning of his chest and responded rapidly to appropriate antimicrobial therapy. Case 2 is that of a relatively healthy 75-year-old woman who also presented to the hospital with pleuritic chest pain but with nonproductive cough. Group C Streptococcus was isolated from both sets of admission blood cultures, and she responded rapidly and completely to appropriate antimicrobial therapy. Neither patient required tube thoracostomy or surgical intervention. These 2 cases and all previously reported cases of Lancefield group C streptococcal pleuropulmonary disease are reviewed herein.