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Nephrotic Syndrome in Leishmaniasis

Iwuji, Collins MB, BS, MSc, MRCP*; Churchill, Duncan FRCP*; Gilleece, Yvonne FRCP*; Kingdon, Edward FRCP†; Wright, David MRCP, FRCPath†; Lucas, Sebastian FRCP, FRCPath‡; Fisher, Martin FRCP*

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181f7438e
Case Reports
Abstract

A 34-year-old white homosexual man presented with advanced human immunodeficiency virus disease and nephrotic syndrome. A renal biopsy demonstrated leishmania organisms in the interstitium and glomeruli, and membranoproliferative glomerulonephritis. Treatment with highly active antiretroviral therapy and liposomal amphotericin led to parasitological clearance and improvement in proteinuria, although treatment discontinuation later led to clinical and parasitological relapse.

Author Information

From the *Department of HIV/Genitourinary Medicine, †Royal Sussex County Hospital, Brighton and Sussex University Hospitals, Brighton and ‡Department of Histopathology, KCL School of Medicine, St Thomas' Hospital, London, UK.

Correspondence to: Collins Iwuji, MB, BS, MSc, MRCP, Lawson Unit, Department of HIV/Genitourinary Medicine, Royal Sussex County Hospital, Eastern Rd, Brighton BN2 5BE, UK. E-mail: collins.iwuji@bsuh.nhs.uk.

Alternate author for correspondence: Martin Fisher, Department of HIV/Genitourinary Medicine, Royal Sussex County Hospital, Brighton and Sussex University Hospitals, Eastern Rd, Brighton, BN2 5BE. E-mail: martin.fisher@bsuh.nhs.uk.

The authors have no funding or conflicts of interest to disclose.

© 2011 Lippincott Williams & Wilkins, Inc.