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Vancomycin-Resistant Enterococcus faecium Meningitis Successfully Treated With Daptomycin in Combination With Doxycycline and Linezolid: Case Report

Lee, Dong Heun MD; Palermo, Brandon MD, MPH; Chowdhury, Mashiul MD

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181e85dcc
Case Reports
Abstract

Enterococcus species are uncommon pathogens in acute bacterial meningitis. Various antibiotics have been used with different outcomes, but optimal therapy has yet to be established owing to the bacteriostatic properties of most agents and the difficulty achieving therapeutic drug concentrations in the central nervous system. We present a case of vancomycin-resistant Enterococcus (VRE) meningitis treated with daptomycin in combination with doxycycline and linezolid and review the previously reported cases.

Author Information

From the Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA.

Correspondence to: Dong Heun Lee, MD, Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, 245 N. 15th St, Philadelphia, PA 19102. E-mail: dong.lee@drexelmed.edu.

M.C. has received honoraria from Cubist. All other authors have no conflicts of interest.

The authors did not receive financial support for this work.

© 2011 Lippincott Williams & Wilkins, Inc.