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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181f0c12a
Review Articles

Pharmacokinetics: Practical Application to Antimicrobial Therapy

Ahern, John W. PharmD*†; Pierce, Kristen K. MD†

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Abstract

Antimicrobial concentrations at the site of infection are an important predictor of antibiotic efficacy. Pharmacokinetics is a subdivision of pharmacology that describes how drug concentrations change as a function of absorption, distribution, and elimination. As a result, pharmacokinetic concepts can be used by practitioners to prescribe and adjust antibacterial dosage regimens so that concentrations are optimal for the treatment of infectious diseases. This article reviews basic pharmacokinetic principles. It also illustrates through practical application the pertinence of pharmacokinetics to antimicrobial therapy.

© 2011 Lippincott Williams & Wilkins, Inc.

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