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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181ee6268
Case Reports

Genital Ulcers Progressing to Fatal Sepsis During Treatment With All-Trans-Retinoic Acid for Acute Promyelocytic Leukemia

Chopra, Teena MD*; Taormina, Mia DO†; Chandrasekar, Pranatharthi MD*‡

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Abstract

Cancer patients receiving chemotherapy may develop genital and perianal ulcers, frequently secondary to herpes simplex infection. Many clinicians would initiate therapy with acyclovir, even without confirmation of the diagnosis of herpes infection. Under such circumstances, drug-induced genital ulcers are not commonly considered. We present a patient with all-trans-retinoic acid-associated genital ulcers progressing to fulminant sepsis.

© 2011 Lippincott Williams & Wilkins, Inc.

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