Invasive fungal infections continue to plague the immunocompromised population, and Fusarium species have become an increasing threat. This species of fungus is a frequent cause of local infections, such as keratitis and onychomycosis, in the immunocompetent but can bring about locally invasive and disseminated infections in the immunocompromised. These infections are associated with a high degree of morbidity and mortality. Patients with neutropenia seem to be particularly susceptible to these manifestations of Fusarium. In invasive and disseminated disease, the primary lesion is often in the sinopulmonary tree or through a wound in the skin. We report here a unique case of primary Fusarium in the gingiva of a patient who underwent hematopoietic stem cell transplant, diagnosed with relapsed acute lymphocytic leukemia that widely disseminated and led to her demise.