Gordonia are a rare cause of human disease and are most commonly reported as causative agents of bacteremia in immunocompromised patients. We describe the second case of pulmonary infection due to Gordonia araii and review all previously published cases of Gordonia infection where clinical information including treatment regimens and outcome are provided. Fifty-one reported cases of Gordonia infection include treatment regimen and clinical outcome. Most cases are catheter-related bloodstream infections or wound infections. Of the 5 cases of Gordonia spp. with pulmonary involvement, 2 individuals died and the other 3 individuals required a mean of 4 months of multidrug therapy. Based on limited case reports, and in contrast to catheter-associated bacteremia and abscesses amenable to surgical drainage, pulmonary involvement with Gordonia appears to be associated with aggressive, necrotizing pneumonia, requires prolonged multidrug therapy, and may require surgical resection for optimal outcome.