A 44-year-old immunocompetent woman was treated for methicillin-resistant Staphylococcus aureus causing abdominal wall cellulitis with incision/drainage and intravenous daptomycin delivered via a midline catheter. The patient presented 5 days later with abdominal pain and spiking fevers. A chest x-ray demonstrated a new right upper lobe infiltrate, and the blood culture grew Serratia rubidaea. The midline catheter was removed, and the patient was successfully treated with intravenous ceftazidime with clinical and bacteriological resolution. This case emphasizes the need to consider unusual species of Serratia in nosocomial sepsis.