Bipolaris is an opportunistic pathogen widely distributed in air, soil, and plants. It is increasingly being recognized as the cause of fungal sinusitis in both normal and immunocompromised hosts. We report a case of disseminated infection due to Bipolaris in a 43-year-old man with prolonged neutropenia after chemotherapy for leukemia. A high-resolution computed tomography (CT) scan of the chest revealed a linear opacity in the right lower lobe, small right pleural effusion, and multiple low-density masses within the liver. A bronchoalveolar lavage was performed, and cultures taken subsequently yielded the fungal pathogen, Bipolaris. The patient was successfully treated with liposomal amphotericin B and posaconazole.