You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Clinical Outcome and Life Quality of Patients After Monophasic Encephalitis

Hahn, Katrin MD*; Schildmann, Eva MD†; von Seggern, Isabell MD‡; Kratzer, Christine MD§; Dietz, Ekkehard PhD∥; Schielke, Eva MD¶

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181e85cec
Original Articles
Abstract

Purpose: Acute encephalitis is a rare disease mainly occurring sporadically. Only limited data as to the long-term prognosis, in particular for impact on quality of life, is available.

Methods: Patients with a definite or highly probable diagnosis of acute encephalitis were identified through retrospective analysis and invited to undertake a structured interview and to fill in questionnaires regarding their quality of life. People who matched the patients in age, sex, and level of education were used as controls.

Results: Seventy-two patients and 57 controls were included. The period between the acute illness and the follow-up amounted to 6 to 93 months. The study showed a favorable outcome with complete or far-reaching functional recovery in most of the patients (83.3%). In cases that progressed in an unfavorable way such that cognitive handicaps were dominant, only 4% were left with extreme physical handicaps. Approximately 22% had postencephalitic epilepsy, which was correlated to a significantly more unfavorable outcome (P < 0.05). Women who have had encephalitis were significantly more depressive than men (P < 0.001) and also noticeably more depressive than female control subjects (P < 0.01). Furthermore, postencephalitic epilepsy was linked with significantly stronger likelihood of depression (P < 0.05).

Conclusions: In this study, most patients had a favorable outcome with complete or far-reaching functional recovery. Postencephalitic epilepsy is a risk factor for an unfavorable outcome and a factor that might hinder coping with the sequelae of acute encephalitis in the long term and that has a negative effect on mood.

Author Information

From the *Department of Neurology, Universitätsmedizin Charité; †Department of Haematology, Oncology and Tumour Immunology, Robert-Rössle-Klinik, Helios Klinikum Berlin-Buch; ‡Departments of Traumatology and Orthopedics, DRK-Klinikum Köpenick Berlin; §Medical Practice; ∥Institutes of Biometry/Clinical Epidemiology, Universitätsmedizin Charité; and ¶Neurological Practice, Berlin, Germany.

Correspondence to: Katrin Hahn, MD, Department of Neurology, University Medicine, Charité, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. E-mail: katrin.hahn@charite.de.

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.