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Cerebral Infarction From Acquired Immunodeficiency Syndrome-Related Cryptococcal Meningitis: An Overlooked Complication of a Common Opportunistic Infection?

Burton, Mary Jane MD*†; Willis, Mary Alissa MD*; Geraci, Stephen A. MD*†; Chapman, Stanley W. MD*; Pappas, Peter G. MD‡

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181b9d34e
Case Reports
Abstract

Despite improved therapies for human immunodeficiency virus and central nervous system cryptococcal infection, early mortality from human immunodeficiency virus-related cryptococcal meningitis remains unchanged. Unrecognized cerebral infarction may be a contributing factor. We believe that serial imaging with higher resolution techniques will lead to increased diagnosis of this often fatal condition. Further studies on adjunctive therapies and the optimal timing of antiretroviral therapy are also needed to improve outcomes in acquired immunodeficiency syndrome-associated cryptococcal meningitis.

Author Information

From the *University of Mississippi Medical Center; †Veterans Affairs Medical Center, Jackson, MS, and ‡University of Alabama at Birmingham, Birmingham, AL.

Reprints: Mary Jane Burton, MD, Medical Service (111), 1500 E Woodrow Wilson Ave, Jackson, MS 39216. E-mail: mary.burton2@va.gov.

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.