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Administering Intravenous Immune Globulin for a Patient With Clostridium difficile Infection and Acute Renal Failure

Hardesty, Jennifer S. PharmD; Juang, Paul PharmD

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181c5ef24
Case Reports

Severe renal adverse effects have been documented after intravenous immune globulin (IVIG) therapy. This is the first reported case of successfully using IVIG to treat a patient with Clostridium difficile infection with concomitant acute renal failure where the patient did not experience a worsening of renal function. The use of IVIG in C. difficile and the mechanism of renal failure secondary to IVIG are reviewed. In addition, a brief overview of IVIG use in patients with acute renal failure is included.

Author Information

From the Division of Pharmacy Practice, St Louis College of Pharmacy, St Louis, MO.

Reprints: Jennifer S. Hardesty, PharmD, Pharmacy Practice, St Louis College of Pharmacy, 4588 Parkview Pl, St Louis, MO, 63110. E-mail:

The authors have no funding or conflicts of interest to disclose.

This material has not been previously presented and is not being submitted concurrently elsewhere.

© 2010 Lippincott Williams & Wilkins, Inc.