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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181b7f7ee
Case Reports

Culture-Negative Endocarditis and the Use of Molecular Diagnostics: A Case Report

de Sanctis, Jorgelina T. MD*; Carpenter, Christopher F. MD*; Sims, Matthew D. MD, PhD*; SenGupta, Dhruba J. PhD†; Prentice, Jennifer L. MS, MT (ASCP)†; Cookson, Brad T. MD, PhD†‡; Boyanton, Bobby L. Jr MD, MT (ASCP)§∥

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Abstract

The management of infective endocarditis (IE) is very challenging in patients with blood cultures negative for a microorganism. Unfortunately, this situation is not uncommon, occurring in up to 30% of cases of IE. Precise microbiological diagnosis, however, is critical to optimize the antibiotic regimen, and thus, non-culture-based molecular techniques are playing a growing role in the care of these patients. We present a patient with culture-negative IE due to Haemophilus parainfluenzae, with the pathogen identified only via molecular techniques.

© 2010 Lippincott Williams & Wilkins, Inc.