The management of infective endocarditis (IE) is very challenging in patients with blood cultures negative for a microorganism. Unfortunately, this situation is not uncommon, occurring in up to 30% of cases of IE. Precise microbiological diagnosis, however, is critical to optimize the antibiotic regimen, and thus, non-culture-based molecular techniques are playing a growing role in the care of these patients. We present a patient with culture-negative IE due to Haemophilus parainfluenzae, with the pathogen identified only via molecular techniques.
From the *Division of Infectious Diseases, William Beaumont Hospital, Royal Oak, MI; Departments of †Laboratory Medicine, and ‡Microbiology,University of Washington, Seattle, WA and Divisions of §Clinical Microbiology, and ∥Molecular Pathology, William Beaumont Hospital, Royal Oak, MI.
Reprints: Jorgelina Teresita de Sanctis, MD, Division Infectious Diseases, William Beaumont Hospital, 3601 W. Thirteen Mile Rd, Royal Oak, MI 48073. E-mail: Jorgelina.firstname.lastname@example.org.
The authors have no funding or conflicts of interest to disclose.