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Culture-Negative Endocarditis and the Use of Molecular Diagnostics: A Case Report

de Sanctis, Jorgelina T. MD*; Carpenter, Christopher F. MD*; Sims, Matthew D. MD, PhD*; SenGupta, Dhruba J. PhD†; Prentice, Jennifer L. MS, MT (ASCP)†; Cookson, Brad T. MD, PhD†‡; Boyanton, Bobby L. Jr MD, MT (ASCP)§∥

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181b7f7ee
Case Reports

The management of infective endocarditis (IE) is very challenging in patients with blood cultures negative for a microorganism. Unfortunately, this situation is not uncommon, occurring in up to 30% of cases of IE. Precise microbiological diagnosis, however, is critical to optimize the antibiotic regimen, and thus, non-culture-based molecular techniques are playing a growing role in the care of these patients. We present a patient with culture-negative IE due to Haemophilus parainfluenzae, with the pathogen identified only via molecular techniques.

Author Information

From the *Division of Infectious Diseases, William Beaumont Hospital, Royal Oak, MI; Departments of †Laboratory Medicine, and ‡Microbiology,University of Washington, Seattle, WA and Divisions of §Clinical Microbiology, and ∥Molecular Pathology, William Beaumont Hospital, Royal Oak, MI.

Reprints: Jorgelina Teresita de Sanctis, MD, Division Infectious Diseases, William Beaumont Hospital, 3601 W. Thirteen Mile Rd, Royal Oak, MI 48073. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.