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Successful Treatment of Invasive Fusarium verticillioides Infection With Posaconazole in a Man With Acute Myelogenous Leukemia

Siegel, Marc MD*†; Kan, Virginia MD†; Varma, Ashok PhD‡; Benator, Debra MD†

Infectious Diseases in Clinical Practice: January 2010 - Volume 18 - Issue 1 - pp 71-74
doi: 10.1097/IPC.0b013e3181b21a01
Case Reports

Infections caused by Fusarium species are now the second most commonly reported mold infections in immunocompromised patients after Aspergillus species. Disseminated Fusarium infections occur most frequently in patients with hematologic malignancies and are associated with unacceptably high mortality rates. Optimal therapy is not well defined, especially in the setting of refractory neutropenia. Although polyenes are still considered the drugs of choice, they have relatively poor in vitro and in vivo efficacy. We report a case of invasive Fusarium verticillioides of the nasal septum in a gentleman with acute myelogenous leukemia who was successfully treated with posaconazole and review the literature regarding therapeutic options.

From the *Division of Infectious Diseases, George Washington University Medical Center; and †Division of Infectious Diseases, Veterans Affairs Medical Center, Washington, DC; and ‡Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Reprints: Marc Siegel, MD, Infectious Diseases Section, VA Medical Center (151B), 50 Irving St, NW, Washington, DC 20422. E-mail: marc.siegel@comcast.net.

The authors have no funding or conflicts of interest to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.