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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181ab2e64
Case Reports

Massive Elevation of Procalcitonin in a Patient With Acquired Immunodeficiency Syndrome Due to Multicentric Castleman Disease

Bissinger, Alfred L. MD*; Schmidt, Susanne M. MD†; Gregor, Michael PhD*; Berg, Christoph MD*; Raible, Armin MD*

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Abstract

A patient with human immunodeficiency virus having lymphadenoma, hepatosplenomegaly, fever, and weight loss was referred to the hospital. Because of a massive rise of procalcitonin, an extensive antibiotic therapy was initiated which, however, did not result in any clinical improvement. Tissue diagnosis revealed a multicentric Castleman disease. After consecutive chemotherapy, procalcitonin levels decreased by less than 3 log suggesting a causative role of multicentric Castleman disease.

© 2010 Lippincott Williams & Wilkins, Inc.