Tuberculosis of the prostate is considered to be a rare disease, and of all the cases of genitourinary tuberculosis, prostatic tuberculosis is much less common in comparison to renal, seminal, and epididymal tuberculoses. It is usually associated with nonspecific symptoms and is detected incidentally after transurethral resection. Sometimes, it may present like acute bacterial infection with high-grade fever and multiple abscesses that is usually seen only in cases of acquired immunodeficiency syndrome. However, the present case showed the previously mentioned features in a human immunodeficiency virus-negative individual and thus creating the diagnostic dilemma. It highlights the facts that prostatic tuberculosis can have a varied presentation and prostatic biopsy with the demonstration of acid-fast bacilli is the criterion standard for diagnosis of this disease.