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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181aba461
Review Articles

The Bidirectional Interactions of Human Immunodeficiency Virus-1 and Sexually Transmitted Infections: A Review

Naresh, Amber MD, MPH*; Beigi, Richard MD, MSc*; Woc-Colburn, Laila MD†; Salata, Robert A. MD†

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Abstract

See pages 357-359 for editorial commentary.

The interactions between human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) have been a major topic of interest since the discovery of HIV in the early 1980s, given the overlapping mechanisms of transmission and shared epidemiology. These interactions manifest themselves in various manners. Human immunodeficiency virus infection, with its attendant immunocompromise, often alters the presentation of STIs and affects their course. Human immunodeficiency virus complicates efficacious therapy and affects management strategies of some STIs. The presence of an STI may increase HIV acquisition by potentiating the susceptibility to and infectivity of HIV. Likewise, HIV infection potentiates the susceptibility to and infectivity of some STIs.

Each of these interactions is examined in this review. Relationships between HIV and gonorrhea, chlamydia, syphilis, herpes simplex virus, chancroid, trichomoniasis, human papilloma virus, and pelvic inflammatory disease are all considered.

© 2009 Lippincott Williams & Wilkins, Inc.