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The Bidirectional Interactions of Human Immunodeficiency Virus-1 and Sexually Transmitted Infections: A Review

Naresh, Amber MD, MPH*; Beigi, Richard MD, MSc*; Woc-Colburn, Laila MD†; Salata, Robert A. MD†

Infectious Diseases in Clinical Practice: November 2009 - Volume 17 - Issue 6 - pp 362-373
doi: 10.1097/IPC.0b013e3181aba461
Review Articles

See pages 357-359 for editorial commentary.

The interactions between human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) have been a major topic of interest since the discovery of HIV in the early 1980s, given the overlapping mechanisms of transmission and shared epidemiology. These interactions manifest themselves in various manners. Human immunodeficiency virus infection, with its attendant immunocompromise, often alters the presentation of STIs and affects their course. Human immunodeficiency virus complicates efficacious therapy and affects management strategies of some STIs. The presence of an STI may increase HIV acquisition by potentiating the susceptibility to and infectivity of HIV. Likewise, HIV infection potentiates the susceptibility to and infectivity of some STIs.

Each of these interactions is examined in this review. Relationships between HIV and gonorrhea, chlamydia, syphilis, herpes simplex virus, chancroid, trichomoniasis, human papilloma virus, and pelvic inflammatory disease are all considered.

From the *Division of Reproductive Infectious Diseases, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA; and †Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH.

Reprints: Amber Naresh, MD, MPH, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213. E-mail: naresha@upmc.edu.

None of the authors have any relevant conflicts of interest related to the data in this manuscript.

© 2009 Lippincott Williams & Wilkins, Inc.