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Streptococcus equi Subspecies zooepidemicus Bacteremia as First Manifestation of Hairy Cell Leukemia

Oever, Jaap ten MD*; Herbers, Alexandra H.E. MD†; Verhoef, Loes H.M. MD‡; van den Wall Bake, A. Warmold L. MD*

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e31819e30ae
Case Reports

A 49-year-old veterinarian presented with a primary bacteremia of Streptococcus equi subsp. zooepidmicus, pancytopenia, and splenomegaly. Hairy cell leukemia (HCL) was diagnosed and successfully treated with cladribine. Group C streptococci are animal pathogens and rarely cause infections in humans. Comorbidity is often essential for acquiring a severe group C streptococci infection. Granulocytopenia and impaired T cell immunity make hairy cell leukemia patients susceptible for severe infections.

Author Information

From the Departments of Internal Medicine, *Máxima Medical Centre, Veldhoven; †Jeroen Bosch Hospital, Den Bosch; and ‡Department of MedicalMicrobiology, Máxima Medical Centre, Veldhoven, The Netherlands.

Reprints: Jaap ten Oever, MD, Máxima Medical Centre, Department of Internal Medicine, PO Box 7777, 5500 MB Veldhoven, The Netherlands. E-mail:

© 2009 Lippincott Williams & Wilkins, Inc.