Actinomyces are filamentous, gram-positive, anaerobic commensals in the oropharyngeal and intestinal tracts in humans. Invasion of breached or necrotic tissue results in infection with this organism. Dental procedures are a well-documented risk factor for local and systemic Actinomyces infections. Actinomyces meyeri can cause serious systemic infections including brain abscesses, endocarditis, osteomyelitis, and empyema, but there are no previous reports of joint involvement with A. meyeri. Skeletal involvement in actinomycosis is usually secondary to local spread from the soft tissues. Hematogenous seeding of bones and joints is extremely rare. We report the first case of A. meyeri bacteremia with septic arthritis of the knee joint in a woman on chronic corticosteroids who underwent a recent dental extraction. We also review the medical literature for the last 30 years of joint involvement as a result of Actinomyces species.