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Immune Thrombocytopenic Purpura During the Course of Acute Hepatitis A Virus Infection

Gultekingil, Ayse MD*; Yarc, Erbu MD*ı; Unal, Sule MD†; Kara, Ates MD‡

Infectious Diseases in Clinical Practice: September 2009 - Volume 17 - Issue 5 - pp 331-332
doi: 10.1097/IPC.0b013e31818add22
Case Reports

Hepatitis A virus infection has many extrahepatic complications, but autoimmune manifestations are rare. Hereby, we present a 10-year-old girl who presented with petechiae, purpura, epistaxis, gingival bleeding, and thrombocytopenia, with a preceding history of hepatitis A virus infection 10 days ago. She was unresponsive to intravenous immunoglobulin treatment, but thrombocytopenia recovered with megadose steroid application. Therefore, megadose steroid may be considered as a treatment alternative in patients unresponsive to intravenous immunoglobulin.

From the *Department of Pediatrics, †Division of Hematology, Department of Pediatrics, and ‡Division of Infectious Diseases, Department of Pediatrics, Ihsan Dogramaci Pediatric Hospital, University of Hacettepe, Ankara, Turkey.

Reprints: Ayse Gultekingil, MD, Department of Pediatrics, Ihsan Dogramaci Pediatric Hospital, University of Hacettepe, Sihhiye/Ankara 06700, Turkey. E-mail: aysegultek@yahoo.com.

© 2009 Lippincott Williams & Wilkins, Inc.