Legionella pneumophila is a common cause of unusually severe pneumonia with multisystem dysfunction. Extrapulmonary manifestations such as myalgias, gastrointestinal, and neurological symptoms may sometimes be predominant with an impressive severity. Abnormalities in laboratory values are likewise nonspecific and can include features of hepatic and renal dysfunction. However, acute liver failure has never been described as the most prominent syndrome. We report a case of fulminant hepatitis probably due to Legionella infection.