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Complete Resolution of a Pulmonary Aspergillosis on Third-Line Posaconazole and Immunosupression Taper After Allogeneic Hematopoietic Cell Transplantation

Mikolajewska, Agata MD*; Genzel, Gelimer MD†; Borte, Gudrun MD‡; Niederwieser, Dietger MD*; Lange, Thoralf MD*

Infectious Diseases in Clinical Practice: September 2009 - Volume 17 - Issue 5 - pp 339-341
doi: 10.1097/IPC.0b013e3181917686
Case Reports

Invasive aspergillosis (IA) is a major cause of mortality in allogeneic hematopoietic stem cell transplant recipients who develop graft-versus-host disease. Here, we report a patient with a probable pulmonary IA after hematopoietic stem cell transplant on cyclosporine A, mycophenolate mofetil, and corticosteroid therapy for graft-versus-host disease who responded to posaconazole after progression of IA on voriconazole and a consecutive caspofungin treatment.

From the *Departments of Hematology/Oncology and Hemostasiology, †Institute for Medical Microbiolgy and Epidemiology of Infectious Diseases, and ‡Diagnostic Radiology, University of Leipzig, Leipzig, Germany.

Reprints: Agata Mikolajewska, MD, Department of Hematology/Oncology, University of Leipzig, Johannisallee 32A, 04103 Leipzig, Germany. E-mail: Agata.Mikolajewska@medizin.uni-leipzig.de.

© 2009 Lippincott Williams & Wilkins, Inc.