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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181917686
Case Reports

Complete Resolution of a Pulmonary Aspergillosis on Third-Line Posaconazole and Immunosupression Taper After Allogeneic Hematopoietic Cell Transplantation

Mikolajewska, Agata MD*; Genzel, Gelimer MD†; Borte, Gudrun MD‡; Niederwieser, Dietger MD*; Lange, Thoralf MD*

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Abstract

Invasive aspergillosis (IA) is a major cause of mortality in allogeneic hematopoietic stem cell transplant recipients who develop graft-versus-host disease. Here, we report a patient with a probable pulmonary IA after hematopoietic stem cell transplant on cyclosporine A, mycophenolate mofetil, and corticosteroid therapy for graft-versus-host disease who responded to posaconazole after progression of IA on voriconazole and a consecutive caspofungin treatment.

© 2009 Lippincott Williams & Wilkins, Inc.