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Prophylaxis for Respiratory Syncytial Virus Infection: A Brief Review

Palumbo, Emilio MD

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e31818b0dba
Review Articles
Abstract

Respiratory syncytial virus (RSV) infects about 15% to 20% of all children younger than 2 years and in the major part of cases results in mild upper respiratory tract disease with a spontaneous resolution, but in a minority (usually infants <6 months old), it causes serious respiratory tract disease. However, in some high-risk pediatric groups (preterm infants, particularly with a gestational age younger than 32 weeks, children with lung disease or affected by pulmonary or cardiac disease and in immunocompromised children), severe lower respiratory tract infection with considerable illness and death is a more frequent occurrence. Palivizumab, a genetically engineered humanized monoclonal antibody, has been shown to reduce RSV-related hospitalizations significantly, with few adverse effects. It was approved for use in high-risk children in the USA in 1998 and in Europe in 1999; it is now approved for use in more than 45 countries. The aim of this review is to evaluate the efficacy and tolerance of this drug in the prevention of RSV infection.

Author Information

From the Department of Pediatric, Hospital of Sondrio, Italy.

Reprints: Emilio Palumbo, MD, via Dell'arc. Michele 4, 71100 Foggia, Italy. E-mail: emipalu2003@yahoo.it.

© 2009 Lippincott Williams & Wilkins, Inc.