Pasteurella multocida is a prevalent cause of zoonotic infections in humans. Most cases are due to animal bites and scratches, but there are reported cases from close contact with animals, mostly cats and dogs. We report a case of P. multocida septicemia in a 50-year-old splenectomized patient with a history of Hodgkin lymphoma from close contact with a rabbit. He did not report any bites or scratches but had close contact with a pet rabbit. The patient was treated successfully with ampicillin. Most of the pathologic strains of Pasteurella are encapsulated. This encapsulation confers resistance to both phagocytosis and complement-mediated destruction of this organism. Our case illustrates the importance of prevention of close contact between splenectomized patients and domestic animals. Carrier states for virulent strains in these animals should be checked to avoid life-threatening septicemia in splenectomized patients.