Two cases of sporotrichosis in persons with human immunodeficiency virus (HIV) infection are reported. Both patients traveled and/or lived in rural areas recognized either as endemic or from where some other non HIV-related cases were reported. In the first case, the patient had a systemic disease with cutaneous, subcutaneous, bone marrow and multiple joint involvement. In the second case, disseminated tuberculosis was concomitantly diagnosed by the time of sporotrichosis diagnosis. Both patients had a good clinical response to intravenous amphotericin B used as primary therapy. Discussions about the clinical aspects and probable pathogenesis and a review of current literature are conducted.
*Departamento de Enfermedades Infecciosas, Transmisibles y Dermatológicas, Hospital Nacional Cayetano Heredia; †Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia; ‡Investigaciones Médicas en Salud (INMENSA) and §Departamento de Medicina, Hospital Nacional Cayetano Heredia, Lima, Peru.
Reprints: Beatriz Bustamante, MD, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Av Honorio Delgado 430. Lima 31, Peru. E-mail: firstname.lastname@example.org.
Javier R. Lama, MD, MPH, and Carlos Mosquera, MD, were affiliated to the Departamento de Enfermedades Infecciosas, Transmisibles y Dermatológicas and Departamento de Medicina, Hospital Nacional Cayetano Heredia in Lima, Peru, by the time the first case reported herein was diagnosed and managed.