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Chikungunya Fever: An Emerging Infection

Cinti, Sandro MD

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e31818a15e5
Review Articles

Recent outbreaks of chikungunya fever in the Indian Ocean and India have raised concern about the epidemic potential of this previously obscure arbovirus. This infection, caused by chikungunya virus (CHIKV), presents with a triad of high fevers, polyarthralgias and a rash. Postinfection arthralgias and fatigue can last months, and recent crude mortality data from afflicted populations suggest that CHIKV may be more virulent than previously thought. In addition, CHIKV attack rates can be higher than 50% in susceptible populations. Finally, Aedes albopictus, the main mosquito vector in the most dramatic epidemic on Reunion Island, is expanding its range worldwide. Thus, there is some concern among public health and arbovirus experts that CHIKV may follow the same epidemic pattern as West Nile Virus did in 1999 in the US. This article will review what is known about CHIKV and address infection in travelers and the potential for worldwide spread.

Author Information

From the University of Michigan Medical School and Veteran's Affairs Ann Arbor Health Systems, Ann Arbor, MI.

Reprints: Sandro Cinti, MD, University of Michigan Hospitals/Veteran's Affairs Ann Arbor Health Systems, 2215 Fuller Rd., Ann Arbor, MI 48105. E-mail:

No funding was obtained for this manuscript and the author has no conflicts of interest.

© 2009 Lippincott Williams & Wilkins, Inc.