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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3181778706
Original Articles

Clinical, Epidemiological, and Laboratory Characteristics of Myocardial Infarction in HIV-1-Infected Patients Receiving Highly Active Antiretroviral Therapy

Calza, Leonardo MD; Cascavilla, Alessandra MD; Pocaterra, Daria MD; Manfredi, Roberto MD; Colangeli, Vincenzo MD; Chiodo, Francesco MD

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Abstract

The aim of this study was to determine the clinical profile and midterm outcome of myocardial infarction (MI) in subjects with HIV infection. We evaluated case sheets of all HIV-1-infected patients with diagnosis of MI referring to our institution from January 2001 to December 2006. Eight patients were included in the study. Their mean age was 49 years (SD, 9 years). Seven patients were on antiretroviral therapy, and the median duration of antiretroviral treatment was 5.6 years (range, 3.5-7.9 years). All the evaluated patients had 3 or more traditional risk factors for coronary artery disease; the mean 10-year risk for coronary events calculated by the Framingham equation just before the MI diagnosis was 7.6% (SD, 2.4%). The frequency of traditional risk factors, prolonged antiretroviral treatment, and HIV infection itself may prompt an increased risk of coronary artery disease in HIV-positive population.

© 2008 Lippincott Williams & Wilkins, Inc.

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