The aim of this study was to determine the clinical profile and midterm outcome of myocardial infarction (MI) in subjects with HIV infection. We evaluated case sheets of all HIV-1-infected patients with diagnosis of MI referring to our institution from January 2001 to December 2006. Eight patients were included in the study. Their mean age was 49 years (SD, 9 years). Seven patients were on antiretroviral therapy, and the median duration of antiretroviral treatment was 5.6 years (range, 3.5-7.9 years). All the evaluated patients had 3 or more traditional risk factors for coronary artery disease; the mean 10-year risk for coronary events calculated by the Framingham equation just before the MI diagnosis was 7.6% (SD, 2.4%). The frequency of traditional risk factors, prolonged antiretroviral treatment, and HIV infection itself may prompt an increased risk of coronary artery disease in HIV-positive population.