With improved survival of adult patients with HIV-infection, providing routine immunizations as a part of chronic disease management is an increasingly important issue for clinicians. Unfortunately, although the burdens of vaccine preventable diseases, such as hepatitis B and pneumococcal disease, are substantial for this patient population, currently available data show that most routine vaccinations are not administered to the majority of patients at risk despite widespread availability. Therefore, this review will discuss for clinicians the data regarding the safety, immunogenicity, and clinical efficacy of vaccines in adults infected with HIV, to make an evidence-based case for increased vaccine utilization in the care of HIV-infected patients.
Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, TX; and The Infectious Disease Clinical Research Program, Bethesda, MD.
Support for this work was provided by the Infectious Disease Clinical Research Program (IDCRP) of the Uniformed Services University of the Health Sciences (USUHS), of which the Tri-Service AIDS Clinical Consortium (TACC) is a component. The IDCRP is a DoD tri-service program executed through USUHS and the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), in collaboration with United States Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases/Division of Clinical Research through Interagency Agreement HU0001-05-2-0011. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or as reflecting the views of the Departments of the Army, Navy, Air Force, or the Department of Defense. The authors have no commercial or other association that might pose a conflict of interest.
Address correspondence to Michael L. Landrum, MD, 3851 Roger Brooke Dr, MCHE-MDI, Fort Sam Houston, TX 78234-6200. E-mail: firstname.lastname@example.org.