Human immunodeficiency virus-associated nephropathy (HIVAN) characterized by proteinuria and progressive renal failure is the single most common cause of chronic kidney disease in HIV-1-seropositive patients. In the pre-highly active antiretroviral therapy (HAART) era, HIVAN was associated with a progressive decline in renal function, culminating in end-stage renal disease requiring dialysis, and typically death secondary to renal failure, opportunistic infection, or other HIV-related end-organ failure. The treatment of this condition is still controversial, but corticosteroids, angiotensin-converting enzyme inhibitors, and HAART have reduced the rate of progression. As yet, there have been no prospective, randomized, controlled trials that document beneficial effect of HAART or of other medical therapies. We report a patient with dialysis-dependent chronic kidney disease secondary to HIVAN who was able to stop dialysis 2 months after initiation of HAART therapy combined with corticosteroids.