Abstract: Kawasaki disease (KD) is a systemic vasculitis and the leading cause of acquired heart disease in the developed world. Kawasaki disease mainly occurs in infants and young children. The illness is rare in infants younger than 3 months. There is no specific diagnostic test or pathognomonic clinical features; clinical criteria have been established to assist physicians in diagnosing KD. So clinician should be aware of the possibility of KD. In this report, we present a case of KD in an infant where the disease manifestation appeared as early as 40 days after birth-perhaps the youngest ever reported from Turkey. Our experience highlights the need to consider KD even in a newborn with a case of prolonged fever.