Aspergillus Infections After Lung Transplantation

Day, Larry J. MD*; Chenoweth, Carol E. MD†‡; Hyde, Kristi Vander MS‡; Lynch, Joseph P. MD§; Iannettoni, Mark MD∥; Clark, Nina M. MD¶

Infectious Diseases in Clinical Practice:
doi: 10.1097/01.idc.0000230548.96251.70
Original Articles
Abstract

Abstract: Invasive fungal infections are a serious consequence of organ transplantation. We observed an increase in Aspergillus infections at our institution among lung transplantation recipients in the year 2000. Records of patients undergoing lung transplantation between 1999 and 2001 were analyzed for evidence of Aspergillus colonization or infection, and potential risk factors for infection were identified. Twenty Aspergillus infections were identified in 103 lung transplant recipients. Thirteen patients had tracheobronchitis, and 7 had invasive pulmonary aspergillosis. Nineteen patients were colonized with Aspergillus. One half of all Aspergillus infections occurred during 2000. There were no differences in demographic or surgical variables, underlying medical illness or postoperative care in association with Aspergillus infection. Factors classically associated with aspergillosis were not found to correlate with an increased risk of infection. Only a specific period of transplantation was significantly associated with Aspergillus infection, suggesting an increased environmental exposure during that period.

Author Information

*University of Hawaii, Honolulu, HI; †Division of Infectious Diseases, Department of Internal Medicine and ‡Department of Infection Control and Epidemiology, University of Michigan Health System, Ann Arbor, MI; §Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, UCLA Medical Center, Los Angeles, CA; ∥Division of Cardiothoracic Surgery, Department of Surgery, University of Iowa, Iowa City, IA and ¶Section of Infectious Diseases, Department of Internal Medicine, University of Illinois at Chicago, Chicago, IL.

Larry J. Day, Joseph P. Lynch, Mark Iannettoni, and Nina M. Clark were affiliated with the University of Michigan Health System at the time the study was conducted.

Address correspondence and reprint requests to Nina M. Clark, MD, Section of Infectious Diseases, Department of Internal Medicine, University of Illinois at Chicago, 808 S. Wood St, Room 888 MC 735, Chicago, IL 60612. E-mail: nmclark@uic.edu.

© 2006 Lippincott Williams & Wilkins, Inc.