Abstract: Salmonella rarely causes focal genital infections. We report a neonate who was hospitalized with fever and a tender erythematous scrotum. Blood cultures were positive for Salmonella. After 4 days of appropriate antibiotic therapy, 5 mL of pus was drained from under the tunica vaginalis of each testicle and was culture-positive for Salmonella. The culprit for bringing the Salmonella into the home was most likely a Savannah monitor. Reptiles pose a risk for causing human Salmonella infections, especially in infants, and should not be kept as pets in households with children younger than 5 years.