: Group G streptococci are infrequently the causes of infection. Previously thought of as nonpathogenic in humans, they have been shown to cause puerperal and neonatal infections, septicemia, skin and soft tissue infections, septic arthritis, endocarditis, meningitis, peritonitis, pleuropulmonary infections, pharyngitis, and otitis media. Group G streptococcal (GGS) bacteremia has frequently been associated with malignancy, alcoholism, and diabetes. Skin and soft tissue infections have been the most common manifestations of infection by these organisms. In our experience with GGS bacteremia at a university hospital, alcoholism emerged as the condition most frequently associated with GGS bacteremia, accounting for 12 (60%) of 20 cases, followed by illicit drug use with seven (35%) of 20 cases and diabetes with six (25%) of 24 cases. An underlying malignancy was present in only 12% of the patients. Four patients had human immunodeficiency virus. Polymicrobial bacteremia was present in one-third of our patients. Skin and soft tissue infections dominated the spectrum of disease.
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