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Implant Dentistry:
doi: 10.1097/ID.0000000000000030
Basic and Clinical Research

Biological Response to β-Tricalcium Phosphate/Calcium Sulfate Synthetic Graft Material: An Experimental Study

Leventis, Minas D. DDS, MS, PhD*; Fairbairn, Peter BDS; Dontas, Ismene DVM, PhD; Faratzis, Gregory MD, DDS, MS, PhD§; Valavanis, Konstantinos D. DDS; Khaldi, Lubna MD, PhD; Kostakis, George MD, DDS, MS, PhD*; Eleftheriadis, Efstathios MD, DDS, PhD#

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Abstract

Purpose:

The aim of this study was to evaluate the effect of a biphasic synthetic bone graft material composed of β-tricalcium phosphate (β-TCP) and calcium sulfate (CS) in 12 New Zealand rabbits.

Materials and Methods:

A circular bicortical critical-size cranial defect was created in each of 12 rabbits. The defects were grafted with β-TCP/CS. Animals were euthanized at 3 and 6 weeks. Harvested tissue specimens were evaluated histologically and histomorphometrically. Parameters associated with new bone formation and graft resorption were measured and calculated. The results were statistically analyzed using the Mann-Whitney test.

Results:

Our data demonstrated the biocompatibility of synthetic β-TCP/CS, as no inflammatory response was observed, and no fibrosis was developed between the graft particles and the newly formed bone. Moreover, β-TCP/CS acted as an osteoconductive scaffold that allowed a significant bone regeneration and graft biodegradation with time.

Conclusion:

In this animal model, synthetic β-TCP/CS proved to be a biocompatible, osteoconductive, and bioresorbable bone graft substitute.

Copyright © 2013 by Lippincott Williams & Wilkins

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