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Diphosphonate Immobilization on Hydroxyapatite-Coated TitaniumMethod Description

Guimarães, Magáli Beck DDS, MScD*; Bueno, Rodrigo Salbego DDS; Guimarães Blaya, Micéli Beck DDS, PhD; Hirakata, Luciana Mayumi DDS, PhD§; Hübler, Roberto BSPHY, PhD

doi: 10.1097/ID.0b013e31828edd13
Basic and Clinical Research

Purpose: The aim of this study was to promote the immobilization of a bone activity biomodulator (diphosphonate) on titanium, commonly used in implant dentistry, to provide a local method of delivering this drug during the osseointegration process.

Methods: The implant material used in this study was commercially wrought titanium (Ticp), 99.9 mass%, grade II. From this material, discs of 15 mm diameter and 1 mm thick were fabricated. These discs underwent 3 sequential surface modification processes: (a) acid-etching, (b) hydroxyapatite coating, and (c) immersion in disodium pamidronate solution. Scanning electron microscopy, X-ray fluorescence, and X-ray diffraction analyses were carried out to characterize the surface created.

Results: The results of these analyses demonstrate that the acid-etching process, followed by the sintering of hydroxyapatite particles and immersion in a solution of disodium pamidronate were effective for diphosphonate immobilization on the titanium surface.

Conclusions: The methodology used in this study allows us to conclude that immersion of hydroxyapatite-coated titanium in a solution of diphosphonate was efficient to promote the immobilization of this drug on the titanium surface.

*Associate Professor of Prosthodontics, School of Dentistry, Centro Universitário Franciscano, Santa Maria, Rio Grande do Sul, Brazil.

Specialist in Implant Dentistry, SOERGS, Porto Alegre, RS, Brazil.

Specialist in Orthodontics, PhD in Dental Materials, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

§Associate Professor of Dental Materials, Department of Prosthodontics, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Assistant Professor of Physics, School of Physics, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Reprint requests and correspondence to: Magáli Beck Guimarães, DDS, MScD, Curso de Odontologia – Centro Universitário Franciscano, Rua dos Andradas, 1614, Centro, CEP 97010-032, Santa Maria, Rio Grande do Sul, Brazil, Phone: (55) 3220-1200, Fax (55) 3222-6484, E-mail: magaliguimaraes@gmail.com

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