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Implant Dentistry:
doi: 10.1097/ID.0b013e31828edd13
Basic and Clinical Research

Diphosphonate Immobilization on Hydroxyapatite-Coated Titanium—Method Description

Guimarães, Magáli Beck DDS, MScD*; Bueno, Rodrigo Salbego DDS; Guimarães Blaya, Micéli Beck DDS, PhD; Hirakata, Luciana Mayumi DDS, PhD§; Hübler, Roberto BSPHY, PhD

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Abstract

Purpose:

The aim of this study was to promote the immobilization of a bone activity biomodulator (diphosphonate) on titanium, commonly used in implant dentistry, to provide a local method of delivering this drug during the osseointegration process.

Methods:

The implant material used in this study was commercially wrought titanium (Ticp), 99.9 mass%, grade II. From this material, discs of 15 mm diameter and 1 mm thick were fabricated. These discs underwent 3 sequential surface modification processes: (a) acid-etching, (b) hydroxyapatite coating, and (c) immersion in disodium pamidronate solution. Scanning electron microscopy, X-ray fluorescence, and X-ray diffraction analyses were carried out to characterize the surface created.

Results:

The results of these analyses demonstrate that the acid-etching process, followed by the sintering of hydroxyapatite particles and immersion in a solution of disodium pamidronate were effective for diphosphonate immobilization on the titanium surface.

Conclusions:

The methodology used in this study allows us to conclude that immersion of hydroxyapatite-coated titanium in a solution of diphosphonate was efficient to promote the immobilization of this drug on the titanium surface.

Copyright © 2013 by Lippincott Williams & Wilkins

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