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Effect of rhBMP-2 Upon Maxillary Sinus Augmentation: A Comprehensive Review

Torrecillas-Martinez, Laura DDS*; Monje, Alberto DDS; Pikos, Michael A. DDS; Ortega-Oller, Inmaculada DDS*; Suarez, Fernando DDS; Galindo-Moreno, Pablo DDS, PhD§; Wang, Hom-Lay DDS, MS, PhD‖,¶

doi: 10.1097/ID.0b013e31829262a8
Clinical Science and Techniques

Purpose: The purpose of this review was to summarize the recent in vitro and in vivo research findings in areas where rhBMP-2 was used as a grafting material for sinus augmentation.

Materials and Methods: An electronic literature search for relevant articles published in English was conducted in the PubMed database from February 1996 to August 2012. Randomized clinical trials or prospective human clinical and animal trials were included with the primary objective to compare and evaluate the effectiveness of rhBMP-2 for sinus augmentation.

Results: A total of 3 human studies and 4 animal trials qualified the selection criteria that were included in this review. In humans, the selected studies indicated that rhBMP-2 induces new bone formation with comparable bone quality or amount of newly formed bone to that induced by autogenous bone graft. Furthermore, no differences have been reported between new bone induced by rhBMP-2 and native bone. Animal model studies also demonstrated regular bone formation induced by rhBMP-2, followed by normal maturation of new bone.

Conclusion: All these studies demonstrate the osteoinductive and osteogenic capacity of rhBMP-2 and support it as an alternative for autogenous bone in sinus floor augmentation.

*Resident, Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.

Resident, Graduate Periodontics, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI.

Private Practice, Palm Harbor, FL.

§Associate Professor, Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.

Professor and Director of Graduate Periodontics, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI.

Research Advisor, Eng. A.B. Research Chair for Growth Factors and Bone Regeneration, King Saud University, Riyadh, Saudi Arabia.

Reprint requests and correspondence to: Hom-Lay Wang, DDS, MSD, PhD, Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109-1078, Phone: 734-763-3383, Fax: 734-936-0374, E-mail: homlay@umich.edu

© 2013 by Lippincott Williams & Wilkins, Inc.