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Comparison Between Unsintered Hydroxyapatite/Poly-L-Lactic Acid Mesh and Titanium Mesh in Bone Regeneration of Rabbit Mandible

Moroi, Akinori DDS*; Ueki, Koichiro DDS, PhD; Okabe, Katsuhiko DDS, PhD; Marukawa, Kohei DDS, PhD§; Sotobori, Megumi DDS*; Mukozawa, Aya DDS*; Miyazakia, Mao DDS*

doi: 10.1097/ID.0b013e31828336be
Basic and Clinical Research

Purpose: The purpose of this study was to compare the bone regenerative capability of using unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) mesh and titanium mesh.

Materials and Methods: Adult male white rabbits (n = 24) were divided into 2 groups. After incising along the mandible, 3 × 5 mm bone defects were made in both sides and covered by an uHA/PLLA mesh (n = 12) or a titanium mesh (n = 12) on the right side but no mesh on the left side (n = 12). The rabbits were sacrificed at 1, 2, and 4 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immunohistochemical analysis, the specimens were treated with BMP-2.

Results: The titanium group and uHA/PLLA group were significantly larger than the control group regarding the bone area ratio postoperatively at 2 and 4 weeks. However, there were no significant differences between the uHA/PLLA group and titanium group regarding the BMP-2.

Conclusions: This study suggested that the uHA/PLLA mesh could increase new bone formation more than the absence of a mesh in bone defects. However, there was no significant difference between uHA/PLLA mesh and the titanium mesh in bone augmentation.

*Graduate Student, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.

Lecturer, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.

Clinical Fellow, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.

§Assistant Professor, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.

Reprint requests and correspondence to: Koichiro Ueki, DDS, PhD, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan, Phone: +81-76-265-2444, Fax: +81-76-234-4268, E-mail: kueki@med.kanazawa-u.ac.jp

© 2013 by Lippincott Williams & Wilkins, Inc.