Purpose: The aim of this study was to evaluate the effect of a new porcine biomaterial and collagen paste in 20 New Zealand rabbits.
Materials and Methods: Forty implants using a porcine xenograft made up of 80% corticocancellous collagenated bone particles of ≤300 μm in size were placed in the proximal metaphyseal area of both tibiae. Four periods of time were formed: 1h, 5, 8, and 15 months. After implantation, an anteroposterior and lateral radiological study was carried out. Samples were sectioned at 5 μm and stained using hematoxylin-eosin, Masson's trichromic, and Gordon-Switt reticulin stains.
Results: These results confirmed the biocompatibility of this porcine biomaterial-collagen paste; only a few, occasional macrophages and scattered lymphocytes were observed. No fibrosis was observed between the implants and the bone. Moreover, the material was osteoconductive acting as a “scaffold” for bone cells, and there was a progressive increase in bone growth in and around the implants.
Conclusion: This new porcine biomaterial-collagen paste seemed to be biocompatible, bioresorbable, and osteoconductive.
*Senior Lecturer of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. †Professor Responsible of Pharmacological Interactions in Dentistry, Dental School, University of Granada, Granada, Spain. ‡Collaborate Professor of Pharmacological Interactions in Dentistry, Dental School, University of Granada, Granada, Spain. §Senior Lecturer of Children Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. ‖Full Professor of Oral Pathology and Medicine, Dental School, University of Chieti-Pescara, Chieti, Italy. ¶Associate Professor of Oral Surgery, Faculty of Medicine, University of Genova, Italy. #Full Professor of Maxillofacial Surgery, School of Dentistry, Complutense University of Madrid; Head of the Department of Oral and Dental Implant Surgery, University Hospital of Madrid, Madrid, Spain. **Orthopedic Surgeon, Unit of Cell Therapy & Bone Bioengineering, University Hospital V. Arrixaca, University of Murcia, Murcia, Spain. ††Collaborate Professor Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. ‡‡Associate Professor of Oral Surgery, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain.
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