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Implant Dentistry:
doi: 10.1097/ID.0b013e3182425991
Basic and Clinical Research

Biological Response to Porcine Xenograft Implants: An Experimental Study in Rabbits

Calvo-Guirado, José Luis DDS, MS, PhD*; Gómez-Moreno, Gerardo DDS, MS, PhD; Guardia, Javier DDS, PhD; Ortiz-Ruiz, Antonio DDS, MS, MD, PhD§; Piatelli, Adriano DDS, PhD, MS, MD; Barone, Antonio DDS, PhD, MS; Martínez-González, José María DDS, MS, MD, PhD#; Meseguer-Olmo, Luis MD, MS, PhD**; López-Marí, Laura DDS††; Dorado, Cristina Barona DDS, PhD, MS‡‡

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Abstract

Purpose: The aim of this study was to evaluate the effect of a new porcine biomaterial and collagen paste in 20 New Zealand rabbits.

Materials and Methods: Forty implants using a porcine xenograft made up of 80% corticocancellous collagenated bone particles of ≤300 μm in size were placed in the proximal metaphyseal area of both tibiae. Four periods of time were formed: 1h, 5, 8, and 15 months. After implantation, an anteroposterior and lateral radiological study was carried out. Samples were sectioned at 5 μm and stained using hematoxylin-eosin, Masson's trichromic, and Gordon-Switt reticulin stains.

Results: These results confirmed the biocompatibility of this porcine biomaterial-collagen paste; only a few, occasional macrophages and scattered lymphocytes were observed. No fibrosis was observed between the implants and the bone. Moreover, the material was osteoconductive acting as a “scaffold” for bone cells, and there was a progressive increase in bone growth in and around the implants.

Conclusion: This new porcine biomaterial-collagen paste seemed to be biocompatible, bioresorbable, and osteoconductive.

© 2012 Lippincott Williams & Wilkins, Inc.

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