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Microvessel Density in Sinus Augmentation Procedures Using Anorganic Bovine Bone and Autologous Bone: 3 Months Results

Degidi, Marco MD, DDS*; Artese, Luciano MD†; Rubini, Corrado MD‡; Perrotti, Vittoria DDS§; Iezzi, Giovanna DDS, PhD¶; Piattelli, Adriano MD, DDS∥

Implant Dentistry:
doi: 10.1097/ID.0b013e3180de4c5f
Basic and Clinical Research

Purpose: This study was an immunohistochemical evaluation of microvessel density (MVD) in sinus augmentation procedures with autologous bone and anorganic bone (Bio-Oss®).

Materials and Methods: Twenty-four patients (14 men and 10 women – mean age of 48 years with a range from 34 to 53 years) participated in this study. All the patients presented a maxillary partial unilateral edentulism involving the premolar/molar areas, with a residual alveolar ridge height of about 4 to 5 mm. Twelve patients received sinus augmentation procedures with 100% autologous bone; 100% Bio-Oss was used in the other 12 patients. Endosseous implants were inserted after a mean period of 3 months. As control, the portions of preexisting subantral bone were used. The mean value of the MVD in control bone was 23.4 +/− 1.3. The mean value of the MVD in the sinuses augmented with autologous bone was 29.0 +/− 2.4. The mean value of the MVD in the sinuses augmented with Bio-Oss was 23.8 +/− 2.2.

Results: The statistical analysis showed that the differences of the MVD between control bone and sinuses augmented with Bio-Oss were not statistically significant (P = 0.52), while the difference of the MVD between sinuses augmented with autologous bone and those augmented with Bio-Oss was statistically significant (P = 0.0008).

Conclusions: Autologous bone may act not only as a passive filling material in bone defects but may also release osteogenic growth factors; and particles of autologous bone seem to contain vital osteoprogenitor cells.

Author Information

*Visiting Professor, Dental School, University of Chieti-Pescara, Italy, Private Practice, Bologna, Italy.

†Professor of Pathology, University of Chieti-Pescara.

‡Researcher, Department of Pathologic Anatomy and Histopathology, University of Ancona, Italy.

§Research Fellow, Dental School, University of Chieti-Pescara.

¶Research Fellow, Dental School, University of Chieti-Pescara.

∥Professor of Oral Pathology and Medicine, Dental School, University of Chieti-Pescara.

Reprint requests and correspondence to:

Prof. Adriano Piattelli, MD, DDS; Via F. Sciucchi 63; 66100 Chieti, Italy; Fax: (011) 39-0871-3554076; E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.