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Journal of Immunotherapy:
doi: 10.1097/CJI.0b013e31826e8f5f
Clinical Studies

Efficacy of Adoptive Cell Transfer of Tumor-infiltrating Lymphocytes After Lymphopenia Induction for Metastatic Melanoma

Pilon-Thomas, Shari*,†; Kuhn, Lisa*; Ellwanger, Sabine; Janssen, William; Royster, Erica§; Marzban, Suroosh§; Kudchadkar, Ragini§; Zager, Jonathan§; Gibney, Geoffrey§; Sondak, Vernon K.*,§; Weber, Jeffrey*,†,§; Mulé, James J.*,†,§; Sarnaik, Amod A.*,§

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Abstract

A single-institution pilot clinical trial was performed combining nonmyeloablative chemotherapy and the adoptive transfer of tumor-infiltrating lymphocytes with interleukin-2 in patients with metastatic melanoma. Nineteen patients were enrolled with 13 patients (68%) successfully completing treatment. An overall response rate (partial and complete responses) of 26% by intention to treat was achieved with a median follow-up time of 10 months. Of the 13 treated patients, there were 2 complete responses and 3 partial responses (38% response rate among treated patients), along with 4 patients with stable disease ranging from 2+ to 24+months. Three of the 4 patients with stable disease have had disease control without additional therapy, including one at 24+ months. Adoptive therapy with infiltrating lymphocytes is labor intensive but feasible and has a high response rate in treated patients.

© 2012 Lippincott Williams & Wilkins, Inc.

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