Home Current Issue Previous Issues Published Ahead-of-Print For Authors Journal Info
Skip Navigation LinksHome > December 1985 - Volume 4 - Issue 6 > An Eastern Cooperative Oncology Group Phase I-II Pilot Study...
Journal of Biological Response Modifiers:
Proceedings: Clinical Studies: PDF Only

An Eastern Cooperative Oncology Group Phase I-II Pilot Study of Polyriboinosinic-Polyribocytidylic Acid Poly-L-lysine Complex in Patients with Metastatic Malignant Melanoma

Hawkins, Michael J.; Levin, Mark; Borden, Ernest C.

Collapse Box

Abstract

Summary: Sixteen patients with metastatic malignant melanoma were treated with poly(I,C)-LC 5 mg/m2 twice weekly by intravenous injection. No antitumor responses occurred. Fever (frequently >40[degrees]C) and fatigue were dose limiting toxicities. One patient developed a fever of 42.2[degrees]C when poly(I,C)-LC was given on 2 consecutive days. Interferon was consistently detected in the serum 8 h after a single injection of poly(I,C)-LC (median titer 199 U/ml). No enhancement of interferon induction was detected on the second day when poly(I,C)-LC was given on 2 consecutive days.

(C) Lippincott-Raven Publishers.

Login

Article Tools

Share

Call for Papers

Journal of Immunotherapy has issued a call for papers. With an impact factor of 3.203, JOI is a leading journal in the fields of immunology and oncology.

For manuscript submission, go to: http://www.editorialmanager.com/jit/

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us

Twitter
twitter.com/JOFIonline

For additional oncology content, visit LWW Oncology Journals on Facebook.