Surgical and Pathological Outcomes of Abdominal Radical Trachelectomy Versus Hysterectomy for Early-Stage Cervical Cancer

Zhang, Dandan MD*‡; Li, Jin MD*‡; Ge, Huijuan MD†‡; Ju, Xingzhu MD*‡; Chen, Xiaojun MD*‡; Tang, Jia MD*‡; Wu, Xiaohua MD, PhD*‡

International Journal of Gynecological Cancer: September 2014 - Volume 24 - Issue 7 - p 1312–1318
doi: 10.1097/IGC.0000000000000185
Cervical Cancer

Objectives: The aim of this study was to compare the surgical and pathological outcomes for patients with early-stage cervical cancer after abdominal radical trachelectomy (ART) and abdominal radical hysterectomy (ARH).

Methods: A prospective database of ART and ARH procedures performed in a standardized manner by the same surgical group was analyzed. The 3-segment technique was used for the accurate analysis of parametrial lymph nodes (PMLNs), and parametrial measurements were recorded by the same pathologist. Standard statistical tests were used.

Result: Between August 2012 and August 2013, ART was attempted in 39 patients (28.6%), and ARH was attempted in 90 patients (71.4%). The parametrium resection length was similar with ART and ARH (44.60 vs 45.48 mm, P = 0.432), as were additional surgical and pathological outcomes, including histology, lymph node positive rate, and operation time. The PMLNs were found in 28 patients (77.78%) in the ART group and in 86 (95.56%) in the ARH group (P > 0.05). Solitary PMLN metastases were observed in 3 patients (10.71%) in the ART group and in 6 (6.98%) in the ARH group. Five (55.6%) of these 9 patients had tumors of 2 cm or greater. The ARH patients (36, 40.00%) were more likely to receive postoperative chemotherapy or radiation compared with ART patients (13, 33.33%; P = 0.017). At a median follow-up of 12 and 12.5 months (P = 0.063), respectively, there were no recurrences or deaths in the ART or ARH groups.

Conclusions: Using standardized techniques, ART provides similar surgical and pathological outcomes as ARH. For the patients with tumors of 2 cm or greater, PMLNs should be examined carefully. Further prospective data are urgently needed.

Departments of *Gynecologic Oncology and †Pathology, Shanghai Cancer Center, Fudan University, Shanghai, PR China; and ‡Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China.

Address correspondence and reprint requests to Xiaohua Wu, MD, Department of Gynecologic Oncology, Cancer Hospital of Fudan University, 270 Dong-an Rd, Shanghai 200032, PR China. E-mail: docwuxh@hotmail.com.

The authors declare no conflicts of interest.

Received March 13, 2014

Received in revised form April 18, 2014

Accepted April 29, 2014

© 2014 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.