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Treatment Options for Pregnant Women With Ovarian Tumors

Mancari, Rosanna MD, PhD*; Tomasi-Cont, Nicoletta MD†‡; Sarno, Maria Anna MD; Azim, Hatem A. Jr MD§; Franchi, Dorella MD; Carinelli, Silvestro MD; Biglia, Nicoletta MD, PhD**; Colombo, Nicoletta MD††; Peccatori, Fedro Alessandro MD, PhD

International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0000000000000161
Review Articles
Abstract

Diagnosis of ovarian mass during pregnancy is a rare event. Treatment of ovarian malignancies during pregnancy depends on histology, grade, stage, and gestational weeks. When possible, surgical excision is indicated, and sometimes, fertility-sparing surgery is recommended. Administration of systemic treatment before or after surgery is indicated as in nonpregnant women. Preliminary data suggest that platinum salts and taxanes are safe during pregnancy. Management of ovarian tumors in pregnancy requires a multidisciplinary approach to guarantee an optimal treatment for the mother and the fetus.

Author Information

*Medical Gynecologic Oncology Division, European Institute of Oncology, Milan, Italy; †Academic Division of Gynaecology and Obstetrics, Mauriziano Hospital “Umberto I,” University of Turin, Turin, Italy; ‡Fertility and Pregnancy Unit, Medical Gynecologic Oncology Division, European Institute of Oncology, Milan, Italy; §Breast Cancer Translational Research Laboratory J.C. Heuson, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; ∥Preventive Gynecology Division and ¶Pathology Division, European Institute of Oncology, Milan, Italy; **Academic Division of Gynaecology and Obstetrics, Mauriziano Hospital “Umberto I,” University of Turin, Turin, Italy; and ††Medical Gynecologic Oncology Division, European Institute of Oncology, University of Milan-Bicocca, Italy.

Address correspondence and reprint requests to Mancari Rosanna, MD, PhD, European Institute of Oncology, Milan, Italy. E-mail: rosanna.mancari@ieo.it.

Supported by Associazione Contro Tumore Ovarico onlus.

The authors declare no conflicts of interest.

Received January 2, 2014

Accepted March 30, 2014

© 2014 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.