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Clinicopathological Features and Survival in Young Taiwanese Women With Endometrial Carcinoma

Lau, Hei-Yu MD*†; Chen, Yi-Jen MD*†; Yen, Ming-Shyen MD*†; Chao, Kuan-Chong MD*†; Chen, Ru-Fen NP†‡; Yeh, Shu-O NP†‡; Twu, Nae-Fang MD*†

International Journal of Gynecological Cancer: July 2014 - Volume 24 - Issue 6 - p 1015–1020
doi: 10.1097/IGC.0000000000000193
Uterine Cancer

Objective: The aim of this study is to compare the clinicopathological features and survival of young women with endometrial cancer (aged <50 years) with those of older women with endometrial cancer (aged ≥50 years).

Methods: We conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the Taipei Veterans General Hospital from 2001 to 2010.

Results: One hundred forty-six patients (28.5%) were aged younger than 50 years at diagnosis. The median follow-up was 36.5 months (range, 0.9–121.7 months). Low body mass index (P < 0.001), nulliparity (P < 0.001), less medical illness (P < 0.001), synchronous primary ovarian cancer (P = 0.001), endometrioid type (P = 0.005), low tumor grade (P < 0.001), no para-aortic lymph node involvement (P < 0.047), less myometrial invasion (P < 0.001), and no vascular space invasion (P = 0.001) were common among the younger women compared with the older women. There were significant differences in the disease-free survival (P = 0.006) and overall survival (P = 0.004) between the 2 groups. In the multivariate Cox model, advanced stage had an effect on both disease-free survival (P = 0.004) and overall survival (P = 0.050).

Conclusions: Nulliparity, body mass index less than or equal to 23 kg/m2, endometrioid type, low-grade tumor, synchronous primary ovarian cancer, and favorable survival were common among the younger women.

*Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital; †Department of Obstetrics and Gynecology, National Yang-Ming University; ‡Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.

Address correspondence and reprint requests to Nae-Fang Twu, MD, Department of Gynecology and Obstetrics, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Rd, Taipei 112, Taiwan, Republic of China. E-mail: nftwu@vghtpe.gov.tw.

The authors declare no conflicts of interest.

Received March 21, 2013

Accepted May 4, 2014

© 2014 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.